Tenidap

Tenidap

SCHEMBL3751880

NC(=O)N1C(=O)C(=C(O)c2cccs2)c2cc(Cl)ccc21

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
HTT P42858 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
PTGS1 P23219 1/20 0.42
PTGS2 P35354 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CNR2 P34972 1/20 0.40
KDM4E B2RXH2 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
LMNA P02545 2/20 0.39
APOBEC3A P31941 1/20 0.39
APOBEC3G Q9HC16 1/20 0.39
OPRM1 P35372 3/20 0.38
OPRD1 P41143 3/20 0.38
OPRK1 P41145 3/20 0.38
CCKBR P32239 1/20 0.38
MAPT P10636 2/20 0.38
ALDH1A1 P00352 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tenidap SCHEMBL3751878 1.00 MEN1 (0.42) MEN1KMT2AHTTCYP1A2CYP2C9
Tenidap SCHEMBL24922 1.00 MEN1 (0.42) MEN1KMT2AHTTCYP1A2CYP2C9
Tenidap SCHEMBL30597938 0.86 KMT2A (0.41) MEN1KMT2AHTTCYP1A2CYP2C9
Tenidap SCHEMBL43098 0.86 KMT2A (0.41) MEN1KMT2AHTTCYP1A2CYP2C9
Tenidap SCHEMBL9216494 0.85 ALDH1A1 (0.33) HTTNPSR1ALDH1A1HSP90AA1
SCHEMBL9215467 0.84 ALDH1A1 (0.36) MEN1KMT2AHTTCYP1A2CYP2C9
SCHEMBL8816115 0.84 CHEK1 (0.41) KMT2AKDM4EALDH1A1RXFP1
SCHEMBL8816112 0.84 CHEK1 (0.41) KMT2AKDM4EALDH1A1RXFP1
SCHEMBL3676246 0.83 ALDH1A1 (0.33) HTTNPSR1ALDH1A1HSP90AA1
Ilonidap SCHEMBL42518 0.83 ALDH1A1 (0.35) MEN1KMT2AHTTCYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7132441-B2 Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor G.D. SEARLE & CO. (US) 2006-11-07 US claimed
US-20230293594-A1 METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS UNIV ROCHESTER (US) 2023-09-21 US disclosed
US-11690876-B2 Methods of treating neuropsychiatric disorders UNIVERSITY OF ROCHESTER (US) 2023-07-04 US disclosed
US-20200197445-A1 METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS UNIVERSITY OF ROCHESTER 2020-06-25 US disclosed
CN-110913689-A Methods of treating neuropsychiatric disorders 罗切斯特大学 2020-03-24 CN disclosed
EP-3621434-A2 METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS University of Rochester (US) 2020-03-18 EP disclosed
WO-2018209022-A2 METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS UNIVERSITY OF ROCHESTER (US) 2018-11-15 WO disclosed
US-20170112860-A1 NOVEL NON-SELECTIVE CATION CHANNEL IN NEURONAL CELLS AND METHODS FOR TREATING BRAIN SWELLING NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-04-27 US disclosed
US-20150272964-A1 NOVEL NON-SELECTIVE CATION CHANNEL IN NEURONAL CELLS AND METHODS FOR TREATING BRAIN SWELLING U.S. OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS 2015-10-01 US disclosed
WO-2015097667-A2 A COMPOSITION, PROCESS OF PREPARATION OF SAID COMPOSITION, KIT AND A METHOD OF TREATING CANCER CELLWORKS GROUP, INC., (US) 2015-07-02 WO disclosed
US-20060276411-A1 Novel non-selective cation channel in neuronal cells and methods for treating brain swelling UNIVERSITY OF MARYLAND, BALTIMORE (US) 2006-12-07 US disclosed
US-7132441-B2 Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor G.D. SEARLE & CO. (US) 2006-11-07 US disclosed
EP-0827399-A1 INHIBITING PHOTODECOMPOSITION OF 3-SUBSTITUTED-2-OXINDOLES PFIZER INC. (US) 1998-03-11 EP disclosed
EP-0681580-B1 PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES PFIZER (US) 1997-07-09 EP disclosed
WO-1997013767-A1 HETEROCYCLICALLY-SUBSTITUTED 1-INDOLE CARBOXAMIDES AS CYCLO-OXYGENASE-2 INHIBITORS CHEMISCH PHARMAZEUTISCHE FORSCHUNGSGESELLSCHAFT MBH (AT) 1997-04-17 WO disclosed
WO-1996033701-A1 INHIBITING PHOTODECOMPOSITION OF 3-SUBSTITUTED-2-OXINDOLES PFIZER INC. (US) 1996-10-31 WO disclosed
EP-0421749-B1 3-Aroyl-2-oxindole-1-carboxamides PFIZER (US) 1995-12-13 EP disclosed
US-5270331-A Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides PFIZER, INC. (US) 1993-12-14 US disclosed
WO-1993002692-A1 METHOD OF COMBATTING HIV INFECTIONS DUKE UNIVERSITY (US) 1993-02-18 WO disclosed
US-5059693-A REDUCTIVE DEHALOGENATION PFIZER INC. (US) 1991-10-22 US disclosed