Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753277 | 0.82 | MAPK1 (0.47) | MAPK1ATMKDM4EALDH1A1MAPT | |
| SCHEMBL3748828 | 0.80 | ALDH1A1 (0.43) | MAPK1KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL3804631 | 0.80 | PDE2A (0.53) | MAPK1ATMKDM4EALDH1A1MAPT | |
| SCHEMBL31325228 | 0.76 | KDM4E (0.39) | MAPK1ATMKDM4EALDH1A1MAPT | |
| SCHEMBL8175471 | 0.75 | MAPT (0.46) | KDM4EALDH1A1MAPTTP53HPGD | |
| SCHEMBL4826028 | 0.73 | KDM4E (0.50) | MAPK1KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL28788055 | 0.73 | PDE2A (0.38) | ALDH1A1MAPTLMNAHPGDKMT2A | |
| SCHEMBL23015355 | 0.72 | MAPK1 (0.40) | MAPK1KDM4EMAPTTP53HSD17B10 | |
| SCHEMBL3808604 | 0.72 | KDM4E (0.42) | MAPK1ATMKDM4EALDH1A1MAPT | |
| SCHEMBL7388810 | 0.71 | PDE2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |