Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 4/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 12/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752882 | 1.00 | APEX1 (0.45) | APEX1AKR1C3MAPTHPGDIMPDH2 | |
| SCHEMBL3745872 | 0.80 | AKR1C3 (0.46) | APEX1AKR1C3 | |
| SCHEMBL13080072 | 0.80 | AKR1C3 (0.46) | APEX1AKR1C3 | |
| SCHEMBL3745875 | 0.80 | AKR1C3 (0.46) | APEX1AKR1C3 | |
| SCHEMBL3758354 | 0.80 | APEX1 (0.46) | APEX1AKR1C3IMPDH2 | |
| SCHEMBL3758348 | 0.80 | APEX1 (0.46) | APEX1AKR1C3IMPDH2 | |
| SCHEMBL13080203 | 0.80 | MEN1 (0.40) | MAPTHPGDIMPDH2 | |
| SCHEMBL3750607 | 0.77 | APEX1 (0.35) | APEX1IMPDH2 | |
| SCHEMBL3750604 | 0.77 | APEX1 (0.35) | APEX1IMPDH2 | |
| SCHEMBL13079414 | 0.77 | ALDH1A1 (0.35) | IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203161-B1 | QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | UNIV INDIANA RES & TECH CORP (US) | 2018-05-09 | — | — | EP | disclosed |
| US-9089605-B2 | Quinone derivatives, pharmaceutical compositions, and uses thereof | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2015-07-28 | — | — | US | disclosed |
| US-20100297113-A1 | QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297113-A1 | QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | APEX1, NQO1, REV1 | APEX1 1/4885AKR1C3 933/4885MAPT 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.