Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 11/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13056668 | 0.91 | GPR142 (0.43) | PIK3CAGPR142ABL1CYP2D6 | |
| SCHEMBL856686 | 0.85 | PIK3CA (0.41) | PIK3CAGPR142ABL1 | |
| SCHEMBL858028 | 0.85 | PIK3CA (0.53) | PIK3CAGPR142 | |
| SCHEMBL3756056 | 0.83 | PIK3CA (0.43) | PIK3CAGPR142 | |
| SCHEMBL3760409 | 0.83 | PIK3CA (0.45) | PIK3CAGPR142ABL1 | |
| SCHEMBL3716268 | 0.82 | PIK3CA (0.42) | PIK3CAGPR142ABL1CYP2D6 | |
| SCHEMBL3715967 | 0.82 | CREBBP (0.47) | PIK3CAGPR142ABL1 | |
| SCHEMBL3757616 | 0.82 | CREBBP (0.47) | PIK3CAGPR142ABL1 | |
| SCHEMBL3757188 | 0.81 | BTK (0.42) | PIK3CA | |
| SCHEMBL3716243 | 0.80 | MTNR1B (0.44) | PIK3CAGPR142CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | claimed |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | PIK3CA 3/4885GPR142 1660/4885ABL1 1058/4885 |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | PIK3CA 3/4885GPR142 2004/4885ABL1 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.