Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794402 | 1.00 | ALDH1A1 (0.53) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL4786329 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL18398773 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL28783740 | 0.82 | POLB (0.50) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL29794411 | 0.82 | POLB (0.50) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL29184110 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL29982859 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL894222 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL29384281 | 0.79 | ALDH1A1 (0.74) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL473877 | 0.79 | ALDH1A1 (0.74) | ALDH1A1MAPK1SMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716435-A | KRAS G12C mutation inhibitor | 广州百霆医药科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| US-7842671-B1 | Peptidomimetic inhibitors of STAT activity and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-11-30 | — | — | US | disclosed |
| US-7342095-B2 | Peptidomimetic inhibitors of STAT activity and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1597270-A2 | PEPTIDOMIMETIC INHIBITORS OF STAT3 ACTIVITY AND THEIR MEDICAL USES | University of South Florida (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050004009-A1 | Peptidomimetic inhibitors of STAT activity and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-01-06 | — | — | US | disclosed |
| WO-2004073650-A2 | PEPTIDOMIMETIC INHIBITORS OF STAT3 ACTIVITY AND THEIR MEDICAL USES | UNIVERSITY OF SOUTH FLORIDA (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004009-A1 | Peptidomimetic inhibitors of STAT activity and uses thereof | STAT3, JAK1, JAK2 | ALDH1A1 4709/4885MAPK1 129/4885SMN1; SMN2 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.