Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27602391 | 0.73 | SLC6A2 (0.40) | SLC6A2SLC6A4DPP4FAPDPP8 | |
| SCHEMBL27644931 | 0.73 | EED (0.48) | SLC6A2SLC6A4KCNH2HTR2AHTR2C | |
| SCHEMBL13576641 | 0.73 | EED (0.48) | SLC6A2SLC6A4KCNH2HTR2AHTR2C | |
| SCHEMBL27288939 | 0.72 | GBA1 (0.43) | SLC6A2SLC6A4DPP4 | |
| SCHEMBL5188031 | 0.72 | PNMT (0.48) | SLC6A2SLC6A4HTR2C | |
| SCHEMBL8330460 | 0.71 | CTSC (0.46) | SLC6A2SLC6A4KCNH2CTSCDPP4 | |
| SCHEMBL3662366 | 0.71 | SLC6A2 (0.56) | SLC6A2SLC6A4KCNH2HTR2AHTR6 | |
| SCHEMBL3444214 | 0.70 | MAOB (0.49) | HTR2A | |
| SCHEMBL10435882 | 0.70 | FLT3 (0.39) | KCNH2 | |
| Hydrochloric Acid SCHEMBL31599129 | 0.70 | SLC6A2 (0.46) | SLC6A2SLC6A4CTSCHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170058-A1 | CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156715-A1 | CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |