Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.81 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.81 |
| ▸ | TUBB | P07437 | 4/20 | 0.81 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.81 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.81 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.81 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.81 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.81 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.81 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.81 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.81 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.81 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.81 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.81 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.81 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23671617 | 1.00 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29815036 | 1.00 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23671618 | 1.00 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30466670 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1764919 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29815038 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30063036 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4967209 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1764918 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5191583 | 0.88 | TUBB1 (0.69) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065358-B1 | THE PREPARTION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD (CN) | 2015-07-08 | — | — | EP | claimed |
| US-7838706-B2 | Preparation and the use of ethoxy combretastatins and their prodrugs | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2010-11-23 | — | — | US | claimed |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2009-07-02 | — | — | US | claimed |
| EP-2065358-A1 | THE PREPARTION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | Zhejiang Dade Pharmaceutical Group Co., Ltd. (CN) | 2009-06-03 | — | — | EP | claimed |
| US-20250074869-A1 | AMINO-COMBRETASTATIN DERIVATIVE AND USE THEREOF | YIWUHUAYAO PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2025-03-06 | — | — | US | disclosed |
| EP-4245750-A1 | AMINO-COMBRETASTATIN DERIVATIVE AND USE THEREOF | YIWUHUAYAO PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2023-09-20 | — | — | EP | disclosed |
| CN-112225673-B | Amino combretastatin derivative and application thereof | 义乌市华耀医药科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-112225673-A | Amino combretastatin derivative and application thereof | 义乌市华耀医药科技有限公司 | 2021-01-15 | — | — | CN | disclosed |
| EP-2065358-B1 | THE PREPARTION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD (CN) | 2015-07-08 | — | — | EP | disclosed |
| CN-103012248-B | Synthesis of amino combretastatin derivative and application of amino combretastatin derivative as oral antitumour drug | ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD | 2014-11-05 | — | — | CN | disclosed |
| EP-2351730-B1 | ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF | SHANGHAI ECUST BIOMEDICINE CO LTD (CN) | 2014-07-30 | — | — | EP | disclosed |
| CN-103012248-A | Synthesis of amino combretastatin derivative and application of amino combretastatin derivative as oral antitumour drug | ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD | 2013-04-03 | — | — | CN | disclosed |
| EP-2351730-A1 | ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF | Shanghai Ecust Biomedicine Co., Ltd (CN) | 2011-08-03 | — | — | EP | disclosed |
| US-7838706-B2 | Preparation and the use of ethoxy combretastatins and their prodrugs | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2010-11-23 | — | — | US | disclosed |
| US-7838706-B2 | Preparation and the use of ethoxy combretastatins and their prodrugs | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2010-11-23 | — | — | US | disclosed |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2009-07-02 | — | — | US | disclosed |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD (CN) | 2009-07-02 | — | — | US | disclosed |
| EP-2065358-A1 | THE PREPARTION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | Zhejiang Dade Pharmaceutical Group Co., Ltd. (CN) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074869-A1 | AMINO-COMBRETASTATIN DERIVATIVE AND USE THEREOF | TUBB3, TUBB6, TUBA3C | TUBB1 7/4885TUBB4A 10/4885TUBB 8/4885 |
| US-20090170956-A1 | PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS | PHOSPHO1, TUBB3, TYMP | TUBB1 5/4885TUBB4A 10/4885TUBB 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.