Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 10/20 | 0.58 |
| ▸ | TUBB | P07437 | 10/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 10/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 10/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 10/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 10/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 10/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 10/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 10/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 10/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 10/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 10/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 10/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 10/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024772 | 0.88 | CYP3A4 (0.65) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6426148 | 0.83 | TUBB4A (0.63) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3748414 | 0.81 | TUBB1 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2130640 | 0.81 | TUBB1 (0.70) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14227747 | 0.81 | TUBB4A (0.43) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14427609 | 0.81 | ABCG2 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3752874 | 0.81 | TUBB1 (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3743123 | 0.80 | TUBB1 (0.54) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13380480 | 0.79 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3741055 | 0.79 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557982-B2 | Tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2013-10-15 | — | — | US | claimed |
| US-20120309768-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2012-12-06 | — | — | US | claimed |
| US-8278290-B2 | Tubulin polymerisation inhibitors | Biononics Limited (AU) | 2012-10-02 | — | — | US | claimed |
| US-20100292190-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-11-18 | — | — | US | claimed |
| EP-1848704-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | Bionomics Limited (AU) | 2007-10-31 | — | — | EP | claimed |
| WO-2006084338-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2006-08-17 | — | — | WO | claimed |
| US-8557982-B2 | Tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2013-10-15 | — | — | US | disclosed |
| US-8557982-B2 | Tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2013-10-15 | — | — | US | disclosed |
| US-20120309768-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2012-12-06 | — | — | US | disclosed |
| US-20120309768-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2012-12-06 | — | — | US | disclosed |
| US-8278290-B2 | Tubulin polymerisation inhibitors | Biononics Limited (AU) | 2012-10-02 | — | — | US | disclosed |
| US-8278290-B2 | Tubulin polymerisation inhibitors | Biononics Limited (AU) | 2012-10-02 | — | — | US | disclosed |
| US-8278290-B2 | Tubulin polymerisation inhibitors | Biononics Limited (AU) | 2012-10-02 | — | — | US | disclosed |
| US-20100292190-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-11-18 | — | — | US | disclosed |
| US-20100292190-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-11-18 | — | — | US | disclosed |
| US-20100292190-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292190-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBA1C, TUBB | TUBB1 1/4885TUBB4A 14/4885TUBB 3/4885 |
| US-20120309768-A1 | NOVEL TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBA1C, TUBB | TUBB1 1/4885TUBB4A 14/4885TUBB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.