Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842227 | 0.82 | RPS6KA3 (0.70) | RPS6KA3MAPTCXCR2CXCR1KDM4E | |
| SCHEMBL8664722 | 0.76 | RPS6KA3 (0.61) | RPS6KA3MAPTKDM4EALDH1A1BLM | |
| SCHEMBL1194456 | 0.76 | RPS6KA3 (0.61) | RPS6KA3MAPTKDM4EALDH1A1BLM | |
| SCHEMBL6866810 | 0.69 | RPS6KA3 (0.53) | RPS6KA3CXCR2CXCR1 | |
| Thiazolopyrimidine SCHEMBL1703410 | 0.68 | RPS6KA3 (0.52) | RPS6KA3MAPTCXCR2CXCR1KDM4E | |
| SCHEMBL338384 | 0.68 | RPS6KA3 (0.52) | RPS6KA3MAPTKDM4EALDH1A1PMP22 | |
| SCHEMBL6975489 | 0.65 | RPS6KA3 (0.49) | RPS6KA3MAPTKDM4EALDH1A1PMP22 | |
| SCHEMBL8435570 | 0.65 | RPS6KA3 (0.49) | RPS6KA3MAPTKDM4EALDH1A1PMP22 | |
| SCHEMBL5036641 | 0.65 | RPS6KA3 (0.48) | RPS6KA3MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4752792 | 0.64 | RPS6KA3 (0.47) | RPS6KA3MAPTHSD17B10SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207774-B1 | TRIAZOLE DERIVATIVES AS SCD INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2016-04-13 | — | — | EP | disclosed |
| US-20120225878-A1 | COMPOUNDS | BOUILLOT ANNE MARIE JEANNE (FR) | 2012-09-06 | — | — | US | disclosed |
| US-8207204-B2 | Triazole derivatives as SCD inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100297097-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297097-A1 | COMPOUNDS | APP, BACE1, SCD | RPS6KA3 3322/4885MAPT 67/4885CXCR2 2674/4885 |
| US-20120225878-A1 | COMPOUNDS | CYP11B2, CYP11B1, SCD | RPS6KA3 2324/4885MAPT 3973/4885CXCR2 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.