Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.50 |
| ▸ | PNP | P00491 | 2/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570271 | 0.81 | PNP (0.47) | RPS6KA3CXCR2PNPCXCR1THRB | |
| SCHEMBL8435574 | 0.81 | PNP (0.47) | RPS6KA3CXCR2PNPCXCR1THRB | |
| SCHEMBL9151696 | 0.69 | KDM4E (0.50) | CXCR2PNPTHRBMITFTP53 | |
| SCHEMBL26155928 | 0.69 | ALDH1A1 (0.45) | RPS6KA3CXCR2PNPCXCR1MAPT | |
| SCHEMBL654655 | 0.68 | MITF (0.44) | RPS6KA3PNPTHRBMITFTP53 | |
| SCHEMBL338384 | 0.68 | RPS6KA3 (0.52) | RPS6KA3PNPTHRBMITFTP53 | |
| SCHEMBL3755970 | 0.68 | RPS6KA3 (1.00) | RPS6KA3CXCR2PNPCXCR1MAPT | |
| SCHEMBL8437718 | 0.67 | CXCR1 (0.45) | CXCR2PNPCXCR1 | |
| SCHEMBL8435033 | 0.67 | CXCR2 (0.45) | CXCR2PNPCXCR1THRBMITF | |
| 8-Aminoguanine SCHEMBL21761 | 0.67 | PNP (1.00) | PNPTHRBMITFTP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220211710-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER WITH NUCLEOSIDE-METABOLISM MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-07-07 | — | — | US | disclosed |
| US-9993491-B2 | Guanine riboswitch binding compounds and their use as antibiotics | SOCPRA—SCIENCES ET GÉNIE S.E.C. (CA) | 2018-06-12 | — | — | US | disclosed |
| EP-2440533-B1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA SCIENCES ET GÉNIE S E C (CA) | 2015-09-23 | — | — | EP | disclosed |
| US-20150150890-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | UNIVERSITE DE SHERBROOKE (CA) | 2015-06-04 | — | — | US | disclosed |
| US-20120122819-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA - SCIENCES ET GENIE S.E.C. (CA) | 2012-05-17 | — | — | US | disclosed |
| EP-2440533-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | Socpra-Sciences Et Génie S.E.C. (CA) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142027-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA - SCIENCES ET GENIE S. E. C. (CA) | 2010-12-16 | — | — | WO | disclosed |
| US-6562969-B1 | Ricin A-chain is an N-glycosidase that attacks ribosomal RNA at a highly conserved adenine residue. Crystallographic studies show that not only adenine and formycin, but also pterin-based rings can bind in the ricin active site. | RESEARCH DEVELOPMENT FOUNDATION | 2003-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150890-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | GDA, RNMT, GNPDA1 | RPS6KA3 2111/4885CXCR2 2597/4885PNP 618/4885 |
| US-20120122819-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | GDA, RNMT, GNPDA1 | RPS6KA3 2111/4885CXCR2 2597/4885PNP 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.