SCHEMBL3755980

SCHEMBL3755980

CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc(N3CC(COS(C)(=O)=O)OC3=O)cc2F)cn1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.43
MAOA P21397 8/20 0.41
CALML3 P27482 2/20 0.38
LMNA P02545 1/20 0.38
PTGS1 P23219 1/20 0.38
SDHA P31040 1/20 0.38
KCNH2 Q12809 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7659799 1.00 MAOB (0.43) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5833572 0.88 CALML3 (0.48) MAOBMAOACALML3LMNAPTGS1
SCHEMBL4012835 0.88 MAOA (0.41) MAOBMAOACALML3LMNAPTGS1
SCHEMBL3757473 0.88 CALML3 (0.48) MAOBMAOACALML3LMNAPTGS1
SCHEMBL3753819 0.88 MAOA (0.41) MAOBMAOACALML3LMNAPTGS1
SCHEMBL8822121 0.87 MAOB (0.43) MAOBMAOACALML3LMNAPTGS1
SCHEMBL7078503 0.85 MAOA (0.39) MAOBMAOACALML3LMNAPTGS1
SCHEMBL7084731 0.85 MAOA (0.39) MAOBMAOACALML3LMNAPTGS1
SCHEMBL4018839 0.85 MAOB (0.48) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5657145 0.85 MAOB (0.48) MAOBMAOACALML3LMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed
US-6495551-B1 P-IMIDAZOLE-PHENYL-OXAZOLIDINES; EFFECTIVE AGAINST GRAMPOSITIVE BACTERIA SYNGENTA LIMITED (GB) 2002-12-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS OXA1L, MIF, VIP MAOB 2709/4885MAOA 3034/4885CALML3 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.