Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.59 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.52 |
| ▸ | CASR | P41180 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750611 | 0.90 | KCNA5 (0.62) | KCNA5P2RX7NPSR1MAPTMAPK1 | |
| SCHEMBL3745343 | 0.87 | KCNA5 (0.78) | KCNA5CASRNPSR1KMT2ASMN1; SMN2 | |
| SCHEMBL3752188 | 0.80 | KCNA5 (0.59) | KCNA5P2RX7CASRKMT2AALDH1A1 | |
| SCHEMBL3759015 | 0.79 | KCNA5 (0.56) | KCNA5P2RX7KMT2AALDH1A1KCNH2 | |
| SCHEMBL3751983 | 0.79 | KCNA5 (0.58) | KCNA5P2RX7CASRKMT2AALDH1A1 | |
| SCHEMBL3751958 | 0.77 | KCNA5 (0.82) | KCNA5SMN1; SMN2ALDH1A1POLBKCNH2 | |
| SCHEMBL3749998 | 0.77 | KCNA5 (0.75) | KCNA5P2RX7KCNH2SCN9ATSHR | |
| SCHEMBL3750640 | 0.76 | KCNA5 (0.59) | KCNA5P2RX7KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3750619 | 0.75 | KCNA5 (0.75) | KCNA5ALDH1A1POLBKCNH2SCN9A | |
| SCHEMBL3754213 | 0.75 | KCNA5 (0.65) | KCNA5P2RX7KMT2AALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | claimed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | KCNA5 69/4885P2RX7 1839/4885CASR 2636/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | KCNA5 72/4885P2RX7 1138/4885CASR 2964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.