SCHEMBL3756223

SCHEMBL3756223

CCOC(=O)c1cnn(-c2ccc([N+](=O)[O-])cc2F)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.49
ALDH1A1 P00352 3/20 0.49
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 4/20 0.47
MITF O75030 1/20 0.47
GABRA2 P47869 1/20 0.45
GABRB2 P47870 1/20 0.45
RAB9A P51151 3/20 0.44
NPC1 O15118 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ELANE P08246 2/20 0.43
KCNJ1 P48048 1/20 0.43
KCNH2 Q12809 1/20 0.43
THRB P10828 1/20 0.42
MAOB P27338 1/20 0.42
AR P10275 1/20 0.42
KCNMA1 Q12791 1/20 0.41
F2 P00734 1/20 0.41
PLAU P00749 1/20 0.41
CTRB1 P17538 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7829415 0.88 CYP1A2 (0.48) MAPTALDH1A1LMNANPC1KDM4E
SCHEMBL20265180 0.87 GABRA2 (0.54) MAPTALDH1A1LMNASMN1; SMN2MITF
SCHEMBL19510606 0.85 NPC1 (0.49) MAPTALDH1A1SMN1; SMN2RAB9ANPC1
SCHEMBL20303502 0.85 GABRA2 (0.49) MAPTALDH1A1SMN1; SMN2MITFGABRA2
SCHEMBL30166642 0.85 GABRA2 (0.49) MAPTALDH1A1SMN1; SMN2MITFGABRA2
SCHEMBL25416054 0.84 ACKR3 (0.47) MAPTALDH1A1LMNASMN1; SMN2GABRA2
SCHEMBL3758177 0.82 CYP1A2 (0.47) MAPTALDH1A1LMNASMN1; SMN2GABRA2
SCHEMBL6157002 0.82 MAPT (0.62) MAPTALDH1A1LMNASMN1; SMN2RAB9A
SCHEMBL28905089 0.80 MAPT (0.42) MAPTALDH1A1SMN1; SMN2GABRA2GABRB2
SCHEMBL6199135 0.79 ALDH1A1 (0.47) MAPTALDH1A1LMNASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed
WO-2007040326-A1 A NOVEL OXAZOLIDINONE FORMAMIDE DERIVATIVE AND PREPARATION METHOD THEROF ILDONG PHARMACEUTICAL CO., LTD (KR) 2007-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS OXA1L, MIF, VIP MAPT 3957/4885ALDH1A1 1845/4885LMNA 4315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.