⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788493 | 0.75 | — | — | |
| SCHEMBL1586143 | 0.75 | — | — | |
| SCHEMBL7123667 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL28432870 | 0.73 | LMNA (0.48) | — | |
| SCHEMBL29882762 | 0.71 | — | — | |
| SCHEMBL11285803 | 0.71 | — | — | |
| SCHEMBL13328683 | 0.71 | — | — | |
| SCHEMBL30828989 | 0.71 | — | — | |
| SCHEMBL4217235 | 0.71 | — | — | |
| SCHEMBL26647314 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481574-B2 | (2Z)-2-(3-butyl-4,5-dimethyl-1,3-thiazol-2(3H)-ylidene)-1-(5-chloro-2-methoxyphenyl)ethanone; antiinflammatory, analgesic agent; autoimmune diseases; neuroprotectants | ABBOTT LABORATORIES (US) | 2013-07-09 | — | — | US | claimed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | claimed |
| EP-0662830-A4 | -G(P)-BOND AROMATIC VITAMIN CHELATES. | — | 1995-08-16 | — | — | EP | claimed |
| EP-0662830-A1 | $g(p)-BOND AROMATIC VITAMIN CHELATES | ALBION INTERNATIONAL, INC. (US) | 1995-07-19 | — | — | EP | claimed |
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | claimed |
| WO-1994004141-A1 | π-BOND AROMATIC VITAMIN CHELATES | ALBION INTERNATIONAL, INC. (US) | 1994-03-03 | — | — | WO | claimed |
| CN-217236238-U | Pyrimidine precipitates crystal drying device | 河南全宇制药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | disclosed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
| EP-0330925-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |
| EP-0328978-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-08-23 | — | — | EP | disclosed |
| EP-0264795-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-04-27 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |
| US-3928327-A | Aroyl alkyledene thiazolines | SHIONOGI & CO | 1975-12-23 | — | — | US | disclosed |