Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thebaine SCHEMBL13154680 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL18457566 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL12137749 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL12646311 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL173212 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL17284777 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL3122741 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL12960959 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL21131556 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL10110846 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8129 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125725-A1 | Compositions And Methods For Making Benzylisoquinoline Alkaloids, Morphinan Alkaloids, Thebaine, And Derivatives Thereof | ANTHEIA INC (US) | 2026-05-07 | — | — | US | claimed |
| US-20260021075-A1 | 2-PENTADECYL-2-OXAZOLINE AS AN OPIOID ADJUVANT TO PREVENT OR TREAT HYPERALGESIA | EPITECH GROUP S.P.A. (IT) | 2026-01-22 | — | — | US | claimed |
| US-20250388939-A1 | RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF L-DOPA, DOPAMINE, S-NOROCLAURINE OR DERIVATIVES THEREOF | RIVER STONE BIOTECH APS (DK) | 2025-12-25 | — | — | US | claimed |
| US-12503706-B2 | Microbial cell with improved in vivo conversion of thebaine/oripavine | RIVER STONE BIOTECH LLC (US) | 2025-12-23 | — | — | US | claimed |
| US-12440489-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2025-10-14 | — | — | US | claimed |
| EP-4615963-A1 | GENETICALLY MODIFIED BENZYLISOQUINOLINE ALKALOID-PRODUCING HOST CELLS WITH MODIFIED EFFLUX TRANSPORTER GENE EXPRESSION | River Stone Biotech ApS (DK) | 2025-09-17 | — | — | EP | claimed |
| US-12416029-B2 | Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof | ANTHEIA INC. (US) | 2025-09-16 | — | — | US | claimed |
| US-20250283129-A1 | PROCESS | SUN PHARMACEUTICAL INDUSTRIES AUSTRALIA PTY LIMITED (AU) | 2025-09-11 | — | — | US | claimed |
| US-12371722-B2 | Recombinant host cells with improved production of L-DOPA, dopamine, S-noroclaurine or derivatives thereof | RIVER STONE BIOTECH APS (DK) | 2025-07-29 | — | — | US | claimed |
| US-20250228771-A1 | ALKALINE INTRAORAL PRODUCTS | EMPLICURE AB (publ) (SE) | 2025-07-17 | — | — | US | claimed |
| US-4277604-A | Facile synthesis of codeine precursors from thebaine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1981-07-07 | — | — | US | claimed |
| EP-0031234-A1 | Analgesic composition | ORTHO PHARMACEUTICAL CORPORATION (US) | 1981-07-01 | — | — | EP | claimed |
| US-4242514-A | Method for the introduction of a methyl group into the 7 position of the morphinan nucleus | MILES LABORATORIES, INC. (US) | 1980-12-30 | — | — | US | claimed |
| EP-0019254-A1 | 7-Methyl and 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them | MILES LABORATORIES, INC. (US) | 1980-11-26 | — | — | EP | claimed |
| US-4140687-A | Process for the preparation of 8-halodihydrocodeinone hydrohalides and codeine | MACFARIAN SMITH LIMITED (GB) | 1979-02-20 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |
| US-4114314-A | CULTURING AND HARVESTING CELLS FROM SEED HEADS OF PAPAVER BRACTEATUM LINDL, POPULATION ARYA II | THE MINISTRY OF SCIENCE & HIGHER EDUCATION (IR) | 1978-09-19 | — | — | US | claimed |
| US-4052402-A | PROCESS FOR SYNTHESIZING CODEINONE FROM THEBAINE | FABRICA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS ABELLO, S.A. (ES) | 1977-10-04 | — | — | US | claimed |
| US-4045440-A | ETHERIFICATION WITH METHYL IODIDE, OXIDATION WITH MANGANESE DIOXIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1977-08-30 | — | — | US | claimed |
| US-4025521-A | REDUCTION OF THEBAINE WITH POTASSIUM IN LIQUID AMMONIA | SHARPS ASSOCIATES (US) | 1977-05-24 | — | — | US | claimed |