Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thebaine SCHEMBL13154680 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL18457566 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL12137749 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL37580 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL173212 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL17284777 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL3122741 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL12960959 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL21131556 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 | |
| Thebaine SCHEMBL10110846 | 1.00 | OPRM1 (1.00) | OPRM1MRGPRX2L3MBTL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136845-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | MALLINCKRODT INC. (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110015219-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | MALLINCKRODT INC. (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2011009015-A1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT INC. (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136845-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | TLR9, TLR3, TLR7 | OPRM1 5/4885MRGPRX2 163/4885L3MBTL1 4120/4885 |
| US-20110015219-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | TLR9, TLR3, TLR1 | OPRM1 17/4885MRGPRX2 198/4885L3MBTL1 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.