Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758113 | 1.00 | MMP13 (0.42) | MMP13DRD2MMP3DRD3ACACB | |
| SCHEMBL8056933 | 0.87 | MMP13 (0.56) | MMP13MMP3 | |
| SCHEMBL8066138 | 0.84 | MMP13 (0.44) | MMP13MMP3 | |
| SCHEMBL3804313 | 0.83 | MMP13 (0.68) | MMP13MMP3 | |
| SCHEMBL3804314 | 0.83 | MMP13 (0.68) | MMP13MMP3 | |
| SCHEMBL3805239 | 0.82 | MMP13 (0.67) | MMP13 | |
| SCHEMBL3805240 | 0.82 | MMP13 (0.67) | MMP13 | |
| SCHEMBL8071049 | 0.79 | MMP13 (0.54) | MMP13MMP3 | |
| SCHEMBL3804190 | 0.78 | MMP13 (0.66) | MMP13 | |
| SCHEMBL8066141 | 0.77 | MMP13 (0.53) | MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |