Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.56 |
| ▸ | CTSL | P07711 | 6/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.56 |
| ▸ | CTSK | P43235 | 9/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27857330 | 0.86 | CTSK (0.55) | CTSSCTSLCTSBCTSKPPARA | |
| SCHEMBL2776839 | 0.86 | CTSK (0.55) | CTSSCTSLCTSBCTSKPPARA | |
| SCHEMBL42878 | 0.86 | CTSK (0.55) | CTSSCTSLCTSBCTSKPPARA | |
| SCHEMBL2366985 | 0.82 | CTSK (0.76) | CTSSCTSLCTSBCTSK | |
| SCHEMBL1823902 | 0.82 | CTSK (0.76) | CTSSCTSLCTSBCTSK | |
| SCHEMBL222158 | 0.82 | CTSK (0.76) | CTSSCTSLCTSBCTSK | |
| SCHEMBL2400096 | 0.81 | CTSS (0.71) | CTSSCTSLCTSBCTSKPPARA | |
| SCHEMBL3824323 | 0.81 | CTSS (0.71) | CTSSCTSLCTSBCTSKPPARA | |
| SCHEMBL8683808 | 0.81 | CTSK (0.62) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7580108 | 0.81 | CTSK (0.62) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |