Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.64 |
| ▸ | TDP2 | O95551 | 2/20 | 0.64 |
| ▸ | NSD2 | O96028 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | G6PD | P11413 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.58 |
| ▸ | EP300 | Q09472 | 3/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 2/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309797 | 0.83 | EP300 (0.68) | MEN1KMT2AMCL1TDP2NSD2 | |
| SCHEMBL13509692 | 0.80 | MCL1 (0.74) | MEN1KMT2AGAAMCL1TDP2 | |
| SCHEMBL14851473 | 0.78 | MCL1 (1.00) | MEN1KMT2AMCL1TDP2NSD2 | |
| SCHEMBL13509795 | 0.78 | STAT3 (0.74) | MEN1KMT2AGAAMCL1TDP2 | |
| SCHEMBL14444625 | 0.76 | MCL1 (0.52) | GAAMCL1ALDH1A1PKMNPC1 | |
| SCHEMBL13510478 | 0.76 | EP300 (0.68) | MEN1KMT2AGAAMCL1TDP2 | |
| SCHEMBL3628790 | 0.76 | KMT2A (0.70) | MEN1KMT2AGAAMCL1TDP2 | |
| SCHEMBL12768396 | 0.75 | KMT2A (0.65) | MEN1KMT2AMCL1TDP2POLB | |
| SCHEMBL15521824 | 0.74 | FSCN1 (0.69) | MEN1KMT2AGAAMCL1TDP2 | |
| SCHEMBL30723346 | 0.74 | FSCN1 (0.69) | MEN1KMT2AGAAMCL1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885GAA 812/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885GAA 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.