Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.68 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CFTR | P13569 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.61 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.61 |
| ▸ | G6PD | P11413 | 1/20 | 0.61 |
| ▸ | FABP4 | P15090 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | BCL2 | P10415 | 3/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.57 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.57 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.57 |
| ▸ | HK1 | P19367 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13510382 | 0.86 | EP300 (0.80) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL3759016 | 0.83 | MEN1 (0.65) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL13510387 | 0.81 | EP300 (1.00) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL588908 | 0.81 | HKDC1 (0.60) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL7587644 | 0.79 | CES1 (0.58) | — | |
| SCHEMBL4954492 | 0.79 | HKDC1 (0.82) | EP300HKDC1KMT2AKEAP1NFE2L2 | |
| SCHEMBL16425752 | 0.79 | EP300 (0.77) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL13509686 | 0.79 | MCL1 (0.71) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL12768396 | 0.78 | KMT2A (0.65) | EP300HKDC1MCL1MEN1POLB | |
| SCHEMBL13510376 | 0.77 | EP300 (0.80) | EP300HKDC1MCL1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |