Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.88 |
| ▸ | RXRB | P28702 | 6/20 | 0.88 |
| ▸ | RXRG | P48443 | 5/20 | 0.88 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.61 |
| ▸ | FEN1 | P39748 | 1/20 | 0.59 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.58 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099618 | 0.94 | RXRA (0.78) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6606655 | 0.88 | RXRA (0.69) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6605970 | 0.86 | RXRA (0.66) | RXRARXRBRXRGPTGER1MCL1 | |
| Acetic Acid SCHEMBL5690407 | 0.84 | RXRA (0.72) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL5620525 | 0.84 | PTGER1 (0.77) | RXRARXRBRXRGPTGER1FEN1 | |
| SCHEMBL3798678 | 0.83 | RXRA (0.71) | RXRARXRBRXRGPTGER1HPGD | |
| SCHEMBL201074 | 0.83 | RXRA (0.70) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6604669 | 0.83 | RXRA (0.62) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL3550156 | 0.83 | RXRA (0.66) | RXRARXRBRXRGHPGDKDM4E | |
| SCHEMBL8846090 | 0.81 | RARB (0.65) | RXRARXRBRXRGPTGER1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842696-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-30 | — | — | US | disclosed |
| US-20090221583-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221583-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | RXRA 1377/4885RXRB 1098/4885RXRG 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.