Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3606455 | 0.84 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL9683882 | 0.78 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL19895559 | 0.74 | OPRM1 (0.40) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL19895560 | 0.74 | OPRM1 (0.40) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL18045301 | 0.73 | KMT2A (0.40) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL18045349 | 0.73 | KMT2A (0.40) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL9682613 | 0.73 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL23532884 | 0.72 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL19078534 | 0.72 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL23532886 | 0.72 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |