Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222165 | 0.77 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL1617607 | 0.71 | KMT2A (0.61) | KMT2AMEN1ALDH1A1DCTPP1CNR2 | |
| SCHEMBL14815988 | 0.71 | KMT2A (0.46) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL15462064 | 0.70 | KMT2A (0.60) | KMT2AMEN1ALDH1A1SMN1; SMN2DCTPP1 | |
| SCHEMBL3528137 | 0.69 | MAPT (0.49) | KMT2AMEN1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL18711924 | 0.67 | KMT2A (0.75) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL31684031 | 0.67 | KMT2A (0.87) | KMT2AMEN1ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL18711931 | 0.66 | KMT2A (0.73) | KMT2AMEN1ALDH1A1DCTPP1LMNA | |
| SCHEMBL27596864 | 0.66 | KMT2A (0.84) | KMT2AMEN1ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL10558121 | 0.65 | KMT2A (0.66) | KMT2AMEN1ALDH1A1SMN1; SMN2DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842696-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-30 | — | — | US | claimed |