Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | NSD2 | O96028 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 2/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562284 | 0.84 | NSD2 (0.62) | KMT2AMEN1NSD2TDP2PLA2G1B | |
| SCHEMBL31684031 | 0.75 | KMT2A (0.87) | KMT2AMEN1GBA1LMNAMAPK1 | |
| SCHEMBL3212651 | 0.74 | HSD11B1 (0.67) | KMT2AMEN1GBA1ALDH1A1HSD11B1 | |
| SCHEMBL27596864 | 0.74 | KMT2A (0.84) | KMT2AMEN1GBA1LMNAHTT | |
| SCHEMBL5349113 | 0.73 | KMT2A (0.61) | KMT2AMEN1GBA1LMNAMAPK1 | |
| SCHEMBL27500250 | 0.73 | KMT2A (0.81) | KMT2AMEN1GBA1LMNAMAPK1 | |
| SCHEMBL4420766 | 0.73 | KMT2A (0.81) | KMT2AMEN1GBA1LMNAMAPK1 | |
| SCHEMBL30032582 | 0.73 | KMT2A (0.81) | KMT2AMEN1GBA1LMNAMAPK1 | |
| SCHEMBL8568869 | 0.72 | NSD2 (0.73) | KMT2AMEN1NSD2TDP2PLA2G1B | |
| SCHEMBL30150274 | 0.72 | KMT2A (0.79) | KMT2AMEN1GBA1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829089-A | ANTIINFLAMMATORY, BRONCHODILATOR | AMERICAN CYANAMID COMPANY (US) | 1989-05-09 | — | — | US | disclosed |
| US-4771061-A | Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation | AMERICAN CYANAMID COMPANY (US) | 1988-09-13 | — | — | US | disclosed |
| US-4686220-A | Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals | AMERICAN CYANAMID COMPANY (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0226842-A2 | Substituted 1,4-naphthalenediones, processes for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1987-07-01 | — | — | EP | disclosed |