SCHEMBL3759581

SCHEMBL3759581

CNC(=O)c1cnccc1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.59
NPC1 O15118 1/20 0.59
ALDH1A1 P00352 1/20 0.50
NUDT1 P36639 1/20 0.46
DGAT2 Q96PD7 1/20 0.46
MAPT P10636 1/20 0.45
PTK2 Q05397 3/20 0.44
NTRK1 P04629 1/20 0.43
RBP4 P02753 1/20 0.43
GAA P10253 3/20 0.41
LMNA P02545 2/20 0.41
P2RX1 P51575 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
MKNK1 Q9BUB5 1/20 0.40
MKNK2 Q9HBH9 1/20 0.40
CSNK1D P48730 1/20 0.39
CSNK1E P49674 1/20 0.39
SCD O00767 1/20 0.39
CFTR P13569 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28163757 0.94 POLB (0.54) POLBNPC1ALDH1A1NUDT1DGAT2
SCHEMBL1417632 0.87 POLB (0.46) POLBNPC1ALDH1A1NUDT1PTK2
SCHEMBL15244373 0.86 NPC1 (0.62) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL5630578 0.85 NPC1 (0.52) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL6081356 0.85 NPC1 (0.61) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL30620178 0.84 NPC1 (0.57) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL29100769 0.84 NPC1 (0.57) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL28064901 0.84 POLB (0.57) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL30620179 0.84 NPC1 (0.57) POLBNPC1ALDH1A1DGAT2MAPT
SCHEMBL3761522 0.84 POLB (0.57) POLBNPC1ALDH1A1DGAT2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0580374-B1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA (JP) 1996-01-03 EP claimed
US-5360806-A Insecticides ISHIHARA SANGYO KAISHA LTD. (JP) 1994-11-01 US claimed
EP-0580374-A1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1994-01-26 EP claimed
CN-110300522-A For preventing and treating the composition that harmful microbe includes 1- (Phenoxy-pyridin base) -2- (1,2,4- triazol-1-yl)-alcohol derivative 拜耳公司 2019-10-01 CN disclosed
CN-110267952-A TRIAZOLETHIONE DERIVATIVES 拜耳公司 2019-09-20 CN disclosed
CN-109982999-A The imidazolyl methyl-derivatives that new 5- replaces 拜耳作物科学股份公司 2019-07-05 CN disclosed
CN-108137538-A TRIAZOLE DERIVATIVES, INTERMEDIATES THEREOF AND THEIR USE AS FUNGICIDES 拜耳作物科学股份公司 2018-06-08 CN disclosed
CN-104478814-A Crystalline modifications of prothioconazole MAKHTESHIM CHEM WORKS LTD 2015-04-01 CN disclosed
CN-102083802-B Crystal modification of prothioconazole MAKHTESHIM CHEM WORKS LTD 2015-02-04 CN disclosed
CN-103068226-B Water-based pesticidal suspension ISHIHARA SANGYO KAISHA 2015-01-07 CN disclosed
US-20130231334-A1 METHODS OF CONTROLLING NEONICOTINOID RESISTANT APHIDS SYNGENTA CROP PROTECTION LLC (US) 2013-09-05 US disclosed
EP-1328154-B1 PESTICIDAL COMPOSITION ISHIHARA SANGYO KAISHA (JP) 2005-07-27 EP disclosed
EP-1476017-A2 COMPOSITION AND METHOD FOR CONTROLLING HOUSE INSECT PEST ISHIHARA SANGYO KAISHA, LTD. (JP) 2004-11-17 EP disclosed
US-20040024026-A1 Pesticidal composition ISHIHARA SANGYO KAISHA, LTD (JP) 2004-02-05 US disclosed
WO-2003069990-A2 COMPOSITION AND METHOD FOR CONTROLLING HOUSE INSECT PEST ISHIHARA SANGYO KAISHA, LTD. (JP) 2003-08-28 WO disclosed
EP-1328154-A1 PESTICIDAL COMPOSITION ISHIHARA SANGYO KAISHA, LTD. (JP) 2003-07-23 EP disclosed
WO-2002034050-A1 PESTICIDAL COMPOSITION ISHIHARA SANGYO KAISHA, LTD. (JP) 2002-05-02 WO disclosed
EP-0580374-B1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA (JP) 1996-01-03 EP disclosed
US-5360806-A Insecticides ISHIHARA SANGYO KAISHA LTD. (JP) 1994-11-01 US disclosed
EP-0580374-A1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1994-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040024026-A1 Pesticidal composition PRDX1, DDT, PRDX6 POLB 2660/4885NPC1 4369/4885ALDH1A1 911/4885
US-20130231334-A1 METHODS OF CONTROLLING NEONICOTINOID RESISTANT APHIDS DDT, AGO2, INF2 POLB 3420/4885NPC1 2554/4885ALDH1A1 4499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.