Sugi Predict

Sugi Predict / Compounds / SCHEMBL375961

SCHEMBL375961

SCHEMBL375961

O=C(O)c1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.59
▸ KDR P35968 1/20 0.54
▸ TRPV1 Q8NER1 1/20 0.52
▸ NPFFR2 Q9Y5X5 1/20 0.51
▸ PGR P06401 1/20 0.50
▸ NOTUM Q6P988 3/20 0.49
▸ PDK1 Q15118 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ MAPT P10636 1/20 0.49
▸ CSNK2A1 P68400 1/20 0.47
▸ KDM4C Q9H3R0 2/20 0.47
▸ KDM2B Q8NHM5 1/20 0.47
▸ SRD5A2 P31213 1/20 0.47
▸ SLC6A3 Q01959 1/20 0.47
▸ HSD11B1 P28845 1/20 0.47
▸ CFTR P13569 1/20 0.46
▸ HTR3E A5X5Y0 1/20 0.46
▸ HTR3B O95264 1/20 0.46
▸ HTR3A P46098 1/20 0.46
▸ HTR3D Q70Z44 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6369011 0.98 TSHR (0.57) TSHRKDRTRPV1NPFFR2PGR
SCHEMBL10656533 0.86 KDR (0.56) KDRTRPV1NPFFR2PGRNOTUM
SCHEMBL17352152 0.85 KDR (0.51) KDRTRPV1NPFFR2PGRNOTUM
SCHEMBL17352154 0.85 KDR (0.51) KDRTRPV1NPFFR2PGRNOTUM
SCHEMBL31542016 0.85 KDR (0.54) KDRTRPV1NPFFR2PGRNOTUM
SCHEMBL29624981 0.85 TSHR (0.59) TSHRKDRTRPV1NOTUMPDK1
SCHEMBL1794695 0.85 KDR (0.54) KDRTRPV1NPFFR2PGRNOTUM
SCHEMBL1920001 0.85 TSHR (0.59) TSHRKDRTRPV1NOTUMPDK1
SCHEMBL1086197 0.83 NPFFR2 (0.58) KDRNPFFR2NOTUMPDK1SLC6A3
SCHEMBL30440617 0.83 NPFFR2 (0.58) KDRTRPV1NPFFR2NOTUMPDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 449 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116355337-B Fluorine-containing polymer-carbon nano tube modified polytetrafluoroethylene and preparation process thereof 山东美氟科技股份有限公司 2023-08-08 — — CN claimed
CN-116355337-A Fluorine-containing polymer-carbon nano tube modified polytetrafluoroethylene and preparation process thereof 山东美氟科技股份有限公司 2023-06-30 — — CN claimed
CN-114539141-A Preparation method of sorafenib 南京焕然生物科技有限公司 2022-05-27 — — CN claimed
EP-3551633-B1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA AS (DK) 2021-03-31 — — EP claimed
CN-108997209-B Preparation method of regorafenib 山东罗欣药业集团恒欣药业有限公司 2020-08-04 — — CN claimed
EP-3403651-B1 ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF LANZHOU INST CHEMICAL PHYSICS CAS (CN) 2019-10-30 — — EP claimed
EP-3551634-A1 SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Leo Pharma A/S (DK) 2019-10-16 — — EP claimed
CN-110088108-A SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS 利奥制药有限公司 2019-08-02 — — CN claimed
CN-108997209-A A kind of preparation method of Rui Gefeini 山东罗欣药业集团恒欣药业有限公司 2018-12-14 — — CN claimed
US-20180334448-A1 Isocorydine derivatives, preparation method and use thereof LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) 2018-11-22 — — US claimed
EP-3403651-A1 ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) 2018-11-21 — — EP claimed
WO-2018108231-A1 SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2018-06-21 — — WO claimed
US-20260092063-A1 FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF JAZZ PHARMACEUTICALS IRELAND LTD (IE) 2026-04-02 — — US disclosed
EP-3500257-B1 KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER ICAHN SCHOOL MED MOUNT SINAI (US) 2025-07-02 — — EP disclosed
US-12304912-B2 Fused bicyclic RAF inhibitors and methods for use thereof JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2025-05-20 — — US disclosed
EP-3976617-B1 FUSED HETEROCYCLIC DERIVATIVES JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2025-04-23 — — EP disclosed
US-4560687-A ANTICONVULSANTS, ANTIEPILEPTIC AGENTS BURROUGHS WELLCOME CO. 1985-12-24 — — US disclosed
US-4493800-A REACTING A TRIFLUOROMETHYLHALOGENOBENZENE WITH COPPER CYANIDE DAIKIN KOGYO CO., LTD. (JP) 1985-01-15 — — US disclosed
EP-0097357-A1 Process for preparing trifluoromethylbenzene derivatives Daikin Kogyo Co., Ltd. (JP) 1984-01-04 — — EP disclosed
EP-0021120-B1 3,5-DIAMINO-1,2,4-TRIAZINE DERIVATIVES, PROCESS FOR PREPARING SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1983-04-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12304912-B2 Fused bicyclic RAF inhibitors and methods for use thereof BRAF, RAF1, NRAS TSHR 3154/4885KDR 1199/4885TRPV1 4634/4885
US-20180334448-A1 Isocorydine derivatives, preparation method and use thereof CCND2, CCND3, IDH3A TSHR 2078/4885KDR 4635/4885TRPV1 4561/4885
US-20260092063-A1 FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF BRAF, NRAS, RAF1 TSHR 912/4885KDR 128/4885TRPV1 4274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.