Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.76 |
| ▸ | EGFR | P00533 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18292548 | 0.84 | KDM4E (0.64) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL17716968 | 0.81 | KDM4E (0.83) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL17717011 | 0.79 | KDM4E (0.76) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL2274986 | 0.78 | NPC1 (0.76) | HTTKDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL1896591 | 0.77 | STAT3 (0.82) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL13197417 | 0.77 | NPC1 (0.74) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL27789999 | 0.76 | FAAH (0.59) | PTGS2EGFRKDM4ESMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4929292 | 0.76 | NPC1 (0.73) | HTTKDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL22589766 | 0.76 | SMN1; SMN2 (0.67) | PTGS2EGFRHTTKDM4ESMN1; SMN2 | |
| SCHEMBL12797730 | 0.76 | NPC1 (0.73) | PTGS2EGFRKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851473-B2 | Amide compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-14 | — | — | US | disclosed |
| US-20080312226-A1 | Amide Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-18 | — | — | US | disclosed |
| EP-1813606-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312226-A1 | Amide Compound | FAAH, FAAH2, CNR2 | PTGS2 127/4885EGFR 4519/4885HTT 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.