Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 1.00 |
| ▸ | CA2 | P00918 | 8/20 | 1.00 |
| ▸ | CA4 | P22748 | 8/20 | 1.00 |
| ▸ | CA7 | P43166 | 8/20 | 1.00 |
| ▸ | CA9 | Q16790 | 8/20 | 1.00 |
| ▸ | CA1 | P00915 | 7/20 | 1.00 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29766352 | 1.00 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL4500272 | 0.78 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL31371162 | 0.77 | ABCC8 (0.67) | CA12CA2CA4CA7CA9 | |
| SCHEMBL10636828 | 0.77 | CA12 (0.62) | CA12CA2CA4CA7CA9 | |
| SCHEMBL16277684 | 0.75 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL8492205 | 0.75 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL375359 | 0.75 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL29766350 | 0.75 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL4501749 | 0.74 | CA12 (0.64) | CA12CA2CA4CA7CA9 | |
| SCHEMBL5186168 | 0.73 | CA12 (0.63) | CA12CA2CA4CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147739-A1 | Novel anti-infectives | SMITHKLINE BEECHAM CORPORATION | 2004-07-29 | — | — | US | claimed |
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | CTXT PTY LIMITED (AU) | 2021-12-09 | — | — | US | disclosed |
| WO-2019043139-A1 | FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY | CTXT PTY LIMITED (AU) | 2019-03-07 | — | — | WO | disclosed |
| EP-2038286-B1 | PYRRO[1,2-B]PYRIDAZINONE COMPOUNDS | ANADYS PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-2038286-B1 | PYRRO[1,2-B]PYRIDAZINONE COMPOUNDS | ANADYS PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-7842838-B2 | Pyrro[1,2-b]pyridazinone intermediates | ANADYS PHARMACEUTICALS, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842838-B2 | Pyrro[1,2-b]pyridazinone intermediates | ANADYS PHARMACEUTICALS, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842838-B2 | Pyrro[1,2-b]pyridazinone intermediates | ANADYS PHARMACEUTICALS, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090312570-A1 | PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090312570-A1 | PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC (US) | 2009-12-17 | — | — | US | disclosed |
| EP-1502916-A1 | PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM | TEIJIN LIMITED (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-20040147739-A1 | Novel anti-infectives | SMITHKLINE BEECHAM CORPORATION | 2004-07-29 | — | — | US | disclosed |
| WO-2004052312-A2 | ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004052313-A2 | ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-1999032467-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-07-01 | — | — | WO | disclosed |
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | KAT5, KAT6A, KAT2A | CA12 4594/4885CA2 4004/4885CA4 4586/4885 |
| US-20040147739-A1 | Novel anti-infectives | RPL5, RPL7, RPL35 | CA12 4222/4885CA2 4750/4885CA4 4527/4885 |
| US-20090312570-A1 | PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS | HAVCR2, CYP4B1, CYP1B1 | CA12 4877/4885CA2 4878/4885CA4 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.