Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091542 | 0.88 | PIM1 (0.67) | PTP4A3KMT2AKDM4EPKMMEN1 | |
| SCHEMBL31358829 | 0.84 | AKT1 (0.67) | PTP4A3KMT2AKDM4EPKMMEN1 | |
| SCHEMBL12990075 | 0.78 | PTP4A3 (1.00) | PTP4A3KMT2AKDM4EMEN1POLB | |
| SCHEMBL3424045 | 0.78 | PTP4A3 (1.00) | PTP4A3KMT2AKDM4EMEN1POLB | |
| SCHEMBL3424039 | 0.78 | PTP4A3 (1.00) | PTP4A3KMT2AKDM4EMEN1POLB | |
| SCHEMBL30287682 | 0.78 | PTP4A3 (1.00) | PTP4A3KMT2AKDM4EMEN1POLB | |
| SCHEMBL13809847 | 0.78 | FASN (0.73) | PTP4A3KMT2AKDM4EPKMMEN1 | |
| SCHEMBL4302098 | 0.78 | FASN (0.73) | PTP4A3KMT2AKDM4EPKMMEN1 | |
| SCHEMBL5147266 | 0.77 | MEN1 (0.67) | PTP4A3KMT2AKDM4EPKMMEN1 | |
| SCHEMBL5147267 | 0.77 | MEN1 (0.67) | PTP4A3KMT2AKDM4EPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | PTP4A3 3184/4885KMT2A 3767/4885KDM4E 2546/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | PTP4A3 3184/4885KMT2A 3767/4885KDM4E 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.