Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.51 |
| ▸ | ANO1 | Q5XXA6 | 7/20 | 0.46 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767340 | 0.78 | ALDH1A1 (0.46) | MAPTTHRBALDH1A1POLBKDM4E | |
| SCHEMBL3756942 | 0.77 | ALDH1A1 (0.39) | MAPTTP53ALDH1A1POLBKDM4E | |
| SCHEMBL31435555 | 0.72 | ALDH1A1 (0.44) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL15902237 | 0.71 | GAA (0.51) | TP53ALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL12443258 | 0.68 | MAPT (0.72) | MAPTTHRBANO1ANO2TP53 | |
| SCHEMBL16681664 | 0.67 | ALOX15 (0.73) | MAPTTHRBANO1ANO2TP53 | |
| SCHEMBL20710947 | 0.65 | ANO1 (0.72) | MAPTTHRBANO1ANO2TP53 | |
| SCHEMBL8206445 | 0.64 | TP53 (0.80) | MAPTTHRBANO1ANO2TP53 | |
| SCHEMBL6991198 | 0.64 | MAPT (0.59) | MAPTTHRBANO1ANO2TP53 | |
| SCHEMBL7886966 | 0.64 | ANO1 (0.59) | MAPTTHRBANO1ANO2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | MAPT 790/4885THRB 839/4885ANO1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.