Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 12/20 | 0.47 |
| ▸ | RAB9A | P51151 | 12/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095774 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL13790283 | 0.86 | MAPT (0.50) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL9982816 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL594726 | 0.83 | MEN1 (0.45) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL15214851 | 0.83 | XDH (0.55) | KDM4EALDH1A1HSD17B10CYP1A2MAPT | |
| SCHEMBL594924 | 0.83 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL10447432 | 0.83 | RAB9A (0.49) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL3755549 | 0.81 | NPC1 (0.59) | KDM4EALDH1A1HSD17B10TSHRMEN1 | |
| SCHEMBL2499930 | 0.81 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 | |
| SCHEMBL2494256 | 0.81 | GSK3B (0.47) | KDM4EALDH1A1HSD17B10TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4182878-A | ANTICARCINOGENIC | THE LION DENTRIFICE CO., LTD. (JP) | 1980-01-08 | — | — | US | claimed |
| US-8349847-B2 | Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents | KONAKANCHI DURGA PRASAD (IN) | 2013-01-08 | — | — | US | disclosed |
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20100298351-A1 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2010-11-25 | — | — | US | disclosed |
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
| US-4182878-A | ANTICARCINOGENIC | THE LION DENTRIFICE CO., LTD. (JP) | 1980-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | KDM4E 2732/4885ALDH1A1 3275/4885HSD17B10 2836/4885 |
| US-20100298351-A1 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS | DPYD, TYMP, TYMS | KDM4E 1866/4885ALDH1A1 309/4885HSD17B10 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.