Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13729454 | 0.91 | MMP13 (0.53) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL8068341 | 0.90 | MMP13 (0.52) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL8065850 | 0.89 | MMP13 (0.53) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL8067164 | 0.88 | MMP13 (0.54) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL13729083 | 0.87 | MMP13 (0.55) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL8066237 | 0.86 | MMP13 (0.49) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL13729214 | 0.86 | MMP13 (0.51) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL13728389 | 0.86 | MMP13 (0.55) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL3692307 | 0.85 | MMP13 (0.51) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL3690357 | 0.85 | MMP13 (0.50) | MMP13ROCK2ROCK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |