Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068341 | 0.89 | MMP13 (0.52) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL3762298 | 0.86 | MMP13 (0.53) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13729454 | 0.86 | MMP13 (0.53) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL8065850 | 0.84 | MMP13 (0.53) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL8067164 | 0.83 | MMP13 (0.54) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13728795 | 0.83 | MMP13 (0.49) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13728792 | 0.83 | MMP13 (0.49) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13837384 | 0.83 | MMP13 (0.49) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13729083 | 0.82 | MMP13 (0.55) | MMP13MEN1KMT2ANOD2ROCK2 | |
| SCHEMBL13728389 | 0.81 | MMP13 (0.55) | MMP13MEN1KMT2ANOD2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |