Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | INSR | P06213 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.44 |
| ▸ | STK3 | Q13188 | 2/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760802 | 0.88 | CDK2 (0.47) | ALKCDK19CDK2INSRALDH1A1 | |
| SCHEMBL3762499 | 0.84 | CDK19 (0.63) | ALKCDK19CDK2IGF1RRET | |
| SCHEMBL3755334 | 0.84 | CDK19 (0.70) | ALKCDK19CDK2INSRIGF1R | |
| SCHEMBL3767846 | 0.83 | CDK19 (0.59) | ALKCDK19INSRIGF1RRET | |
| SCHEMBL3762013 | 0.83 | CDK2 (0.62) | CDK2ALDH1A1IGF1RKDRGSK3B | |
| SCHEMBL3757040 | 0.82 | IGF1R (0.55) | CDK2INSRIGF1RRETPRKD3 | |
| SCHEMBL3761753 | 0.81 | CDK2 (0.52) | CDK2INSRIGF1RABL1EGFR | |
| SCHEMBL3759158 | 0.80 | CDK2 (0.51) | CDK2INSRIGF1RMAP4K4LCK | |
| SCHEMBL3765209 | 0.80 | CDK2 (0.52) | CDK2INSRIGF1REGFRCDK4 | |
| SCHEMBL3761151 | 0.80 | CDK2 (0.56) | CDK2INSRIGF1REGFRCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435436-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8354422-B2 | Pyrimidine inhibitors of kinase activity | ABBOTT LABORATORIES INC. (US) | 2013-01-15 | — | — | US | disclosed |
| WO-2010138576-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | IGF1R, CDK2, TK1 | ALK 534/4885CDK19 53/4885CDK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.