Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943948 | 0.89 | KCNA5 (0.70) | KCNA5KCNH2MDM2FFAR1P2RX7 | |
| SCHEMBL3744483 | 0.87 | KCNA5 (0.77) | KCNA5KCNH2MDM2P2RX7ABCB1 | |
| SCHEMBL3756606 | 0.86 | KCNA5 (0.76) | KCNA5KCNH2MDM2P2RX7ALDH1A1 | |
| SCHEMBL3753606 | 0.85 | KCNA5 (0.85) | KCNA5KCNH2MDM2P2RX7ALDH1A1 | |
| SCHEMBL3756386 | 0.85 | KCNA5 (0.68) | KCNA5KCNH2MDM2FFAR1P2RX7 | |
| SCHEMBL3756665 | 0.85 | KCNA5 (0.77) | KCNA5KCNH2P2RX7ALDH1A1 | |
| SCHEMBL3758397 | 0.85 | KCNA5 (0.73) | KCNA5KCNH2P2RX7 | |
| SCHEMBL3758356 | 0.84 | KCNA5 (1.00) | KCNA5KCNH2MDM2P2RX7ALDH1A1 | |
| SCHEMBL3749069 | 0.83 | KCNA5 (0.80) | KCNA5KCNH2MDM2P2RX7ALDH1A1 | |
| SCHEMBL3755834 | 0.82 | KCNA5 (0.75) | KCNA5KCNH2MDM2P2RX7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | KCNA5 69/4885KCNH2 2/4885MDM2 3686/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | KCNA5 72/4885KCNH2 2/4885MDM2 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.