Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Maleic Anhydride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Anhydride SCHEMBL6254674 | 0.97 | ALDH1A1 (0.33) | ALDH1A1TSHRHSP90AA1GMNNLMNA | |
| Maleic Anhydride SCHEMBL29209460 | 0.95 | HSP90AA1 (0.32) | ALDH1A1TSHRHSP90AA1 | |
| Maleic Anhydride SCHEMBL4731435 | 0.88 | HSP90AA1 (0.32) | ALDH1A1HSP90AA1CYP2C9HPGDALOX15 | |
| Maleic Anhydride SCHEMBL3816979 | 0.85 | HSP90AA1 (0.31) | ALDH1A1TSHRHSP90AA1CYP2C9HPGD | |
| Maleic Anhydride SCHEMBL4658562 | 0.85 | MGLL (0.33) | ALDH1A1HSP90AA1GMNNLMNAMAPT | |
| Maleic Anhydride SCHEMBL193675 | 0.84 | — | — | |
| Maleic Anhydride SCHEMBL10545341 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TSHRLMNAMGLLMEN1 | |
| Maleic Anhydride SCHEMBL28986958 | 0.82 | HSP90AA1 (0.30) | ALDH1A1HSP90AA1CYP2C9HPGDALOX15 | |
| Maleic Anhydride SCHEMBL27932202 | 0.82 | MGLL (0.32) | ALDH1A1HSP90AA1GMNNLMNAMAPT | |
| Maleic Anhydride SCHEMBL28161522 | 0.81 | TSHR (0.30) | TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117378710-A | Composite plant extract, preparation method and application | 福建傲农生物科技集团股份有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-116515196-A | Halogen-free low-smoke flame-retardant crosslinked polyethylene material and preparation method thereof | 东莞市安高瑞新材料科技有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-111995699-B | Method for preparing agarose | 集美大学 | 2022-07-19 | — | — | CN | claimed |
| CN-113844152-A | Manufacturing method of antibacterial moisturizing pet urinal pad | 江苏中恒宠物用品股份有限公司 | 2021-12-28 | — | — | CN | claimed |
| CN-110003362-B | Preparation method of high-transparency high-gel-strength modified agar | 福建省绿麒食品胶体有限公司 | 2021-09-21 | — | — | CN | claimed |
| CN-111995699-A | Method for preparing agarose | 集美大学 | 2020-11-27 | — | — | CN | claimed |
| CN-110256265-A | A kind of preparation method of diethylenetriamine disuccinic acid tetrasodium salt metal-chelator | 青岛中科荣达新材料有限公司 | 2019-09-20 | — | — | CN | claimed |
| CN-110003362-A | A kind of preparation method of the modified agar of high grade of transparency high-gel strength | 福建省绿麒食品胶体有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-105255395-B | Heat-resistant and waterproof building binder and preparation method thereof | 宁波远欣石化有限公司 | 2017-01-25 | — | — | CN | claimed |
| US-7674480-B2 | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2010-03-09 | — | — | US | claimed |
| EP-1566176-B1 | Synergistic antibacterial formulation and a method of making the same | KHANDELWAL SANJEEV (IN) | 2008-07-16 | — | — | EP | claimed |
| EP-1566176-A1 | Synergistic antibacterial formulation and a method of making the same | Khandelwal, Sanjeev Prem Nivas (IN) | 2005-08-24 | — | — | EP | claimed |
| US-20050181051-A1 | Synergistic antibacterial formulation and to a method of making the same | KHANDELWAL SANJEEV (IN) | 2005-08-18 | — | — | US | claimed |
| CN-118026905-A | Method for synthesizing N-methylpyrrolidone by maleic anhydride hydrogenation | 河北师范大学 | 2024-05-14 | — | — | CN | disclosed |
| CN-116655841-B | Continuous solution polymerization method and system | 中国石油天然气股份有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117624442-A | Fluorocarbon resin emulsion polymerization method | 山东东岳未来氢能材料股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2002070021-A1 | GASTRIC DELIVERY OF ANTINEOPLASTIC AGENTS AND METHODS OF TREATMENT VIA INHIBITION OF CANCER CELL USING THEM | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2002-09-12 | — | — | WO | disclosed |
| WO-2002000213-A1 | RAPIDLY EXPANDING COMPOSITION FOR GASTRIC RETENTION AND CONTROLLED RELEASE OF THERAPEUTIC AGENTS, AND DOSAGE FORMS INCLUDING THE COMPOSITION | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2002-01-03 | — | — | WO | disclosed |
| EP-1074269-A2 | Disposable water-absorbent structure | UNI-CHARM CORPORATION (JP) | 2001-02-07 | — | — | EP | disclosed |
| US-4810807-A | MIXED OXIDES OF COPPER, ZINC AND ALUMINUM | THE STANDARD OIL COMPANY (US) | 1989-03-07 | — | — | US | disclosed |