Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28725982 | 0.95 | PRMT5 (0.41) | PRMT5WDR77MAOBKMT2ATRIM24 | |
| SCHEMBL8846954 | 0.72 | CHRNB2 (0.49) | PRMT5WDR77KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4019471 | 0.72 | CHRNB2 (0.49) | PRMT5WDR77KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8846952 | 0.72 | CHRNB2 (0.49) | PRMT5WDR77KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8542500 | 0.71 | CHRNB2 (0.47) | PRMT5WDR77KMT2AMEN1CHRNB2 | |
| SCHEMBL8540149 | 0.71 | CHRNB2 (0.47) | PRMT5WDR77KMT2AMEN1CHRNB2 | |
| SCHEMBL8540152 | 0.71 | CHRNB2 (0.47) | PRMT5WDR77KMT2AMEN1CHRNB2 | |
| SCHEMBL19514190 | 0.70 | NPC1 (0.42) | PRMT5WDR77KMT2ATRIM24TRIM33 | |
| Hydrochloric Acid SCHEMBL9050213 | 0.70 | CHRNB2 (0.46) | KMT2AMEN1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL3757414 | 0.70 | ALDH1A1 (0.41) | KMT2ASMN1; SMN2POLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | disclosed |