Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018135 | 0.96 | ALDH1A1 (0.46) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3010628 | 0.92 | L3MBTL1 (0.50) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3008296 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3019810 | 0.91 | HSD17B10 (0.46) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3644344 | 0.88 | ALDH1A1 (0.43) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3021657 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3008397 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3014834 | 0.86 | ALDH1A1 (0.47) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3004887 | 0.85 | MEN1 (0.47) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL3012814 | 0.85 | MEN1 (0.48) | ALDH1A1MEN1TSHRKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |