Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.51 |
| ▸ | TUBB | P07437 | 5/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715874 | 0.84 | NPC1 (0.42) | LMNAMAPK1SMN1; SMN2ALDH1A1TUBB4A | |
| SCHEMBL6126460 | 0.79 | LMNA (0.63) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL11378313 | 0.76 | LMNA (0.53) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL11379777 | 0.76 | LMNA (0.53) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL10727499 | 0.75 | LMNA (0.55) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 | |
| Carbendazim SCHEMBL8427009 | 0.75 | LMNA (0.71) | LMNAHIF1ACYP1A2SMN1; SMN2KDR | |
| Carbendazim SCHEMBL21051 | 0.75 | LMNA (0.71) | LMNAHIF1ACYP1A2SMN1; SMN2KDR | |
| Carbendazim SCHEMBL29357746 | 0.75 | LMNA (0.71) | LMNAHIF1ACYP1A2SMN1; SMN2KDR | |
| SCHEMBL5037530 | 0.74 | LMNA (0.64) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL11402164 | 0.74 | TUBB4A (0.76) | LMNAHIF1AMAPK1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | LMNA 2593/4885HIF1A 1872/4885MAPK1 119/4885 |
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | LMNA 2817/4885HIF1A 2051/4885MAPK1 134/4885 |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | LMNA 2157/4885HIF1A 1737/4885MAPK1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.