Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.71 |
| ▸ | CASP3 | P42574 | 1/20 | 0.71 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.71 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.70 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 7/20 | 0.64 |
| ▸ | MMP3 | P08254 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.64 |
| ▸ | MMP13 | P45452 | 2/20 | 0.64 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | NSD2 | O96028 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764677 | 1.00 | KMT2A (0.71) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL6884607 | 0.89 | PTPN22 (0.69) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL20558643 | 0.89 | PTPN12 (0.65) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL20558641 | 0.89 | PTPN12 (0.65) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL6884614 | 0.89 | PTPN22 (0.69) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL20558691 | 0.88 | PTPN12 (0.64) | KMT2APTPN12PTPN22AKR1B1MMP3 | |
| SCHEMBL20558693 | 0.88 | PTPN12 (0.64) | KMT2APTPN12PTPN22AKR1B1MMP3 | |
| SCHEMBL29377571 | 0.88 | PTPN12 (0.64) | KMT2APTPN12PTPN22AKR1B1MMP3 | |
| SCHEMBL12008720 | 0.88 | FABP4 (0.74) | KMT2AMEN1GAAPOLBHSP90AA1 | |
| SCHEMBL9393527 | 0.86 | PDE4B (0.78) | KMT2AMEN1POLBAKR1B1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100304998-A1 | Chemical Proteomic Assay for Optimizing Drug Binding to Target Proteins | MARQUETTE UNIVERSITY (US) | 2010-12-02 | — | — | US | disclosed |