Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756186 | 0.90 | EGLN3 (0.50) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3756929 | 0.89 | EGLN3 (0.53) | EGLN3RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL3519839 | 0.87 | EGLN3 (0.38) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3761712 | 0.86 | EGLN3 (0.38) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3519877 | 0.85 | CASP1 (0.36) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3519403 | 0.84 | EGLN3 (0.40) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3524105 | 0.83 | LMNA (0.49) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3524259 | 0.82 | EGLN3 (0.52) | LMNAEGLN3HSD17B10RAB9ANPC1 | |
| SCHEMBL3519608 | 0.81 | EGLN3 (0.58) | EGLN3RAB9ANPC1MAPK1TOP1 | |
| SCHEMBL3520873 | 0.81 | EGLN3 (0.40) | LMNAEGLN3HSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | LMNA 3042/4885EGLN3 2/4885HSD17B10 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.