Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 9/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161774 | 0.83 | GRM5 (0.46) | BRD4GRM5PIK3CAPIK3R1PDE2A | |
| SCHEMBL3754871 | 0.78 | PIK3CA (0.43) | BRD4GRM5PIK3CAPIK3R1PDE2A | |
| SCHEMBL3766781 | 0.73 | PIK3CD (0.45) | BRD4GRM5PIK3CAPIK3R1PDE2A | |
| SCHEMBL16161712 | 0.71 | HTT (0.47) | BRD4GRM5PIK3CAPIK3R1PDE2A | |
| SCHEMBL15848941 | 0.69 | PIK3CA (0.38) | BRD4GRM5PIK3CAPIK3R1GRM4 | |
| SCHEMBL3764957 | 0.69 | PIK3CA (0.42) | BRD4PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3759332 | 0.69 | PIK3CA (0.44) | BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3758960 | 0.69 | PIK3CA (0.40) | BRD4GRM5PIK3CAPIK3R1HSD17B10 | |
| SCHEMBL3243835 | 0.68 | PTGS2 (0.36) | BRD4GRM5PIK3CAPIK3R1GRM4 | |
| SCHEMBL3763646 | 0.68 | PIK3CA (0.41) | BRD4GRM5PIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | BRD4 1041/4885GRM5 2081/4885PIK3CA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.