Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.35 |
| ▸ | GRM5 | P41594 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119485 | 0.74 | PIK3CA (0.48) | PIK3CAGRM5PIK3R1BRD4PIK3CD | |
| SCHEMBL3265059 | 0.73 | PIK3CA (0.43) | PIK3CAGRM5BRD4 | |
| SCHEMBL3121821 | 0.73 | PIK3CA (0.44) | PIK3CAGRM5NPC1RAB9A | |
| SCHEMBL3130106 | 0.73 | PIK3CA (0.48) | PIK3CAGRM5PIK3R1BRD4PIK3CD | |
| SCHEMBL16161774 | 0.70 | GRM5 (0.46) | PIK3CAGRM5PIK3R1BRD4PIK3CD | |
| SCHEMBL3754871 | 0.70 | PIK3CA (0.43) | PIK3CAGRM5PIK3R1BRD4GRM4 | |
| SCHEMBL3120379 | 0.69 | PIK3CA (0.41) | PIK3CAGRM5NPC1 | |
| SCHEMBL3116360 | 0.69 | GRM5 (0.50) | PIK3CAGRM5MTORNPC1RAB9A | |
| SCHEMBL3765027 | 0.68 | BRD4 (0.36) | PIK3CAGRM5PIK3R1BRD4GRM4 | |
| SCHEMBL16161712 | 0.67 | HTT (0.47) | PIK3CAGRM5PIK3R1BRD4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |