Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 6/20 | 0.60 |
| ▸ | LCK | P06239 | 4/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | MAP4K5 | Q9Y4K4 | 4/20 | 0.60 |
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759773 | 0.83 | IGF1R (0.63) | IGF1RMAPK8EGFRERBB2MAPK10 | |
| SCHEMBL3761539 | 0.83 | IGF1R (0.63) | CDK2KITFLT3IRAK4JAK2 | |
| SCHEMBL3762095 | 0.81 | CDK2 (0.54) | CAMK2DCDK2LCKKDRMAP4K5 | |
| SCHEMBL3760568 | 0.81 | CDK2 (0.74) | CAMK2DCDK2LCKKDRMAP4K5 | |
| SCHEMBL1789167 | 0.81 | IGF1R (0.71) | CDK2LCKKDRMAP4K5CSF1R | |
| SCHEMBL1871349 | 0.81 | IGF1R (0.64) | CDK2LCKKDRMAP4K5CSF1R | |
| SCHEMBL1788491 | 0.80 | IGF1R (0.61) | CAMK2DCDK2LCKKDRMAP4K5 | |
| SCHEMBL1788634 | 0.79 | IGF1R (0.62) | CDK2LCKKDRMAP4K5CSF1R | |
| SCHEMBL3759323 | 0.79 | CDK2 (0.56) | CAMK2DCDK2LCKKDRMAP4K5 | |
| SCHEMBL1789150 | 0.78 | IGF1R (0.67) | CAMK2DCDK2LCKKDRMAP4K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435436-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8354422-B2 | Pyrimidine inhibitors of kinase activity | ABBOTT LABORATORIES INC. (US) | 2013-01-15 | — | — | US | disclosed |
| WO-2010138576-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | IGF1R, CDK2, TK1 | CAMK2D 904/4885CDK2 2/4885LCK 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.