Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 15/20 | 0.49 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765241 | 1.00 | TYMP (0.49) | TYMPPOLA1 | |
| SCHEMBL3771375 | 1.00 | TYMP (0.49) | TYMPPOLA1 | |
| SCHEMBL5055945 | 0.91 | TYMP (0.52) | TYMP | |
| SCHEMBL3767163 | 0.82 | TYMP (0.34) | TYMP | |
| SCHEMBL7656894 | 0.80 | TYMP (0.51) | TYMP | |
| SCHEMBL7656887 | 0.80 | TYMP (0.51) | TYMP | |
| SCHEMBL3771295 | 0.80 | HIF1A (0.48) | POLA1 | |
| SCHEMBL17069757 | 0.78 | TYMP (0.40) | TYMP | |
| SCHEMBL5055951 | 0.78 | TYMP (0.52) | TYMP | |
| SCHEMBL29975248 | 0.77 | TYMP (0.51) | TYMPPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7847075-B2 | 2-Azapurine compounds and their use | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-20090306360-A1 | 2-AZAPURINE COMPOUNDS AND THEIR USE | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| US-7612187-B2 | 2-azapurine compounds and their uses | ROCHE DIAGNOSTICS, GMBH (DE) | 2009-11-03 | — | — | US | disclosed |
| US-7169553-B1 | 2-Azapurine compounds and their use | ROCHE DIAGNOSTICS, GMBH (DE) | 2007-01-30 | — | — | US | disclosed |
| US-20070015725-A1 | 2-azapurine compounds and their uses | ROCHE DIAGNOSTICS, GMBH (US) | 2007-01-18 | — | — | US | disclosed |
| EP-1214331-B1 | 2-AZAPURINE COMPOUNDS AND THEIR USE | ROCHE DIAGNOSTICS GMBH (DE) | 2006-10-11 | — | — | EP | disclosed |
| EP-1214331-A2 | 2-AZAPURINE COMPOUNDS AND THEIR USE | Roche Diagnostics GmbH (DE) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016149-A2 | 2-AZAPURINE COMPOUNDS AND THEIR USE | ROCHE DIAGNOSTICS GMBH (DE) | 2001-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306360-A1 | 2-AZAPURINE COMPOUNDS AND THEIR USE | ADAR, AMPD2, NSUN2 | TYMP 12/4885POLA1 687/4885 |
| US-20070015725-A1 | 2-azapurine compounds and their uses | ADAR, NSUN2, AMPD2 | TYMP 12/4885POLA1 723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.