Sugi Predict

Sugi Predict / Compounds / SCHEMBL3765736

SCHEMBL3765736

SCHEMBL3765736

CS(=O)(=O)c1ccn[c]c1-c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 7/20 0.37
▸ THRB P10828 2/20 0.36
▸ PTGS1 P23219 2/20 0.36
▸ ALDH1A1 P00352 3/20 0.35
▸ HPGD P15428 2/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ LMNA P02545 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ CYP2C9 P11712 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ HTT P42858 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ POLB P06746 1/20 0.33
▸ RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3759980 0.72 PDE10A (0.36) ALDH1A1HPGDL3MBTL1KDM4EKMT2A
SCHEMBL16720034 0.71 PTGS2 (0.39) PTGS2THRBPTGS1ALDH1A1HPGD
SCHEMBL3758958 0.71 SMN1; SMN2 (0.33) PTGS2PTGS1ALDH1A1HPGDL3MBTL1
SCHEMBL6022854 0.70 PTGS2 (0.38) PTGS2THRBPTGS1ALDH1A1HPGD
SCHEMBL3761229 0.69 SMN1; SMN2 (0.40) ALDH1A1HPGDKDM4ECYP1A2KMT2A
SCHEMBL3759693 0.68 CYP2A6 (0.37) ALDH1A1HPGDL3MBTL1LMNAKDM4E
SCHEMBL3751748 0.68 BACE1 (0.38) ALDH1A1HPGDL3MBTL1LMNAKDM4E
SCHEMBL3758939 0.68 ALDH1A1 (0.37) THRBALDH1A1HPGDLMNAKDM4E
SCHEMBL2399248 0.68 NOTUM (0.34) ALDH1A1L3MBTL1KMT2ASMN1; SMN2RAB9A
SCHEMBL3760100 0.68 KMT2A (0.38) PTGS2THRBALDH1A1L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029570-B1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA SA (BE) 2014-10-15 — — EP disclosed
US-8324204-B2 Fused thiophene derivatives as kinase inhibitors UCB PHARMA SA (BE) 2012-12-04 — — US disclosed
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors UCB PHARMA S.A. (BE) 2010-12-02 — — US disclosed
WO-2009122148-A1 FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS PI3K KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-10-08 — — WO disclosed
WO-2009071895-A1 FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-06-11 — — WO disclosed
WO-2009071890-A1 TRICYCLIC KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-06-11 — — WO disclosed
EP-2029570-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB Pharma S.A. (BE) 2009-03-04 — — EP disclosed
WO-2007141504-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2007-12-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors PIKFYVE, PI4KA, PIK3CA PTGS2 1169/4885THRB 839/4885PTGS1 1147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.