Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | CASP6 | P55212 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vincamine SCHEMBL14095103 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL147179 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL30892136 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL29710919 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL8970683 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL8134417 | 0.99 | CYP3A4 (0.98) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL6631357 | 0.98 | CYP3A4 (0.96) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL5712113 | 0.98 | CYP3A4 (0.96) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL6162410 | 0.97 | CYP3A4 (0.95) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL11619815 | 0.97 | CYP3A4 (0.93) | CYP3A4KCNH2CYP2D6HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 103741 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239899-A1 | TCR MIMIC MONOCLONAL ANTIBODIES REACTIVE WITH THE PHOSPHO-NEOANTIGEN PIRS2/HLA-A*02:01 COMPLEX AND USES THEREOF | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2024-07-18 | — | — | US | claimed |
| US-20240239799-A1 | (S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER | C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2024-07-18 | — | — | US | claimed |
| WO-2024148437-A1 | USE OF PCLX-001 OR PCLX-002 AS A RADIOSENSITIZER | PACYCLEX PHARMACEUTICALS INC. (CA) | 2024-07-18 | — | — | WO | claimed |
| WO-2024151548-A2 | PROCESS FOR PURIFICATION OF CHEMICAL COMPONENTS FROM PLANT MATTER | KB CRASH CREATINS LLC (US) | 2024-07-18 | — | — | WO | claimed |
| EP-3868409-B1 | THIOPHENOL-MALEIMIDE AND BROM-MALEIMIDE DERIVATIVES AS LINKER FOR ANTIBODY-DRUG CONJUGATES (ADC) FOR TREATING TUMORS | REMEGEN CO LTD (CN) | 2024-07-17 | — | — | EP | claimed |
| CN-112912076-B | Use of carbamate compounds for preventing, alleviating or treating diabetic peripheral neuropathy or chemotherapy-induced peripheral neuropathy | 爱思开生物制药株式会社 | 2024-07-16 | — | — | CN | claimed |
| CN-114786682-B | Fibronectin type III domain binding CD71 | ARO生物疗法公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118354776-A | Methods and compositions for enhanced efficacy and reduced toxicity of non-implanted CD8 depleted allogeneic donor lymphocyte infusions | 约翰霍普金斯大学 | 2024-07-16 | — | — | CN | claimed |
| US-12037379-B2 | CD71 binding fibronectin type III domains | Aro Biotherapeutics Company (US) | 2024-07-16 | — | — | US | claimed |
| CN-118355033-A | Compositions and methods comprising anti-NRP 2a antibodies | ATYR 医药公司 | 2024-07-16 | — | — | CN | claimed |
| EP-0062457-A2 | Improvements in or relating to the production of chemical compounds | UNITED KINGDOM ATOMIC ENERGY AUTHORITY (GB) | 1982-10-13 | — | — | EP | claimed |
| US-4309415-A | LINOLENIC ACID OR DERIVATIVE WITH MATERIAL WHICH ENHANCES BIOSYNTHESIS OF THROMBOXANE A2 | VERRONMAY LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| EP-0041030-A1 | Compositions for topical use containing Ergot or Vinca Rosea alkaloids for treatment of hyperseborrhoea, and their preparation | PIERRE FABRE S.A. (FR) | 1981-12-02 | — | — | EP | claimed |
| EP-0037175-A1 | Pharmaceutical compositions | EFAMOL LIMITED (GB) | 1981-10-07 | — | — | EP | claimed |
| EP-0035856-A2 | Pharmaceutical and dietary compositions | EFAMOL LIMITED (GB) | 1981-09-16 | — | — | EP | claimed |
| US-4279817-A | Method for producing dimer alkaloids | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 1981-07-21 | — | — | US | claimed |
| US-4172077-A | Process for the isolation of alkaloid components from the plant Vinca Rosea L. | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1979-10-23 | — | — | US | claimed |
| EP-0004770-A2 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1979-10-17 | — | — | EP | claimed |
| US-3965254-A | Compositions for the treatment of calcific tumors | THE PROCTER & GAMBLE COMPANY (US) | 1976-06-22 | — | — | US | claimed |
| US-3932417-A | Dimeric indole alkaloid purification process | ELI LILLY AND COMPANY (US) | 1976-01-13 | — | — | US | claimed |