Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.96 |
| ▸ | MEN1 | O00255 | 3/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.96 |
| ▸ | MAPT | P10636 | 2/20 | 0.96 |
| ▸ | GAA | P10253 | 1/20 | 0.96 |
| ▸ | CASP6 | P55212 | 1/20 | 0.96 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.96 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vincamine SCHEMBL30892136 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL8970683 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL3767 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL29710919 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL14095103 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL147179 | 0.98 | CYP3A4 (1.00) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL6675845 | 0.97 | CYP3A4 (0.92) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL8134417 | 0.97 | CYP3A4 (0.98) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL5712113 | 0.96 | CYP3A4 (0.96) | CYP3A4KCNH2CYP2D6HIF1AMEN1 | |
| Vincamine SCHEMBL7462345 | 0.96 | CYP3A4 (0.89) | CYP3A4KCNH2CYP2D6HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574317-B1 | A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor | ROUSSEL UCLAF (FR) | 1996-10-09 | — | — | EP | claimed |
| EP-0488383-B1 | 2-beta,19-ethylene bridged steroids as aromatase inhibitors | MERRELL PHARMA INC (US) | 1996-09-11 | — | — | EP | claimed |
| EP-0574317-A1 | A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor | ROUSSEL UCLAF (FR) | 1993-12-15 | — | — | EP | claimed |
| EP-1309594-B1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1309594-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012239-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-02-14 | — | — | WO | disclosed |
| EP-0574317-B1 | A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor | ROUSSEL UCLAF (FR) | 1996-10-09 | — | — | EP | disclosed |
| EP-0574317-A1 | A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor | ROUSSEL UCLAF (FR) | 1993-12-15 | — | — | EP | disclosed |
| EP-0059146-B1 | MEDICAMENTS DERIVED FROM 3-HYDROXY DODECAHYDRO BENZ(E) INDEN-7-ON, PRODUCTS DERIVED FROM 3-HYDROXY DODECAHYDRO BENZ(E) INDEN-7-ON AND PROCESS FOR THEIR PREPARATION | ROUSSEL-UCLAF (FR) | 1985-09-25 | — | — | EP | disclosed |
| EP-0059146-A1 | Medicaments derived from 3-hydroxy dodecahydro benz(e) inden-7-on, products derived from 3-hydroxy dodecahydro benz(e) inden-7-on and process for their preparation | ROUSSEL-UCLAF (FR) | 1982-09-01 | — | — | EP | disclosed |