Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190605 | 0.88 | MAPT (0.52) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL11413069 | 0.87 | NPC1 (0.49) | HTR1AADRA1DADRA1AADRA1BTDP1 | |
| SCHEMBL1119402 | 0.87 | MAPT (0.51) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL3324126 | 0.82 | MAOB (0.54) | L3MBTL1MAOB | |
| SCHEMBL6614268 | 0.81 | NPC1 (0.52) | HTR1AADRA1DADRA1AADRA1BAPP | |
| SCHEMBL28034423 | 0.80 | MAPT (0.40) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL7294363 | 0.79 | L3MBTL1 (0.46) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL314855 | 0.79 | CA1 (0.39) | L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL8732802 | 0.79 | MAPT (0.46) | HTR1AL3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL368084 | 0.78 | TSHR (0.44) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017034377-A1 | PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | WO | claimed |
| US-20170057955-A1 | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | US | claimed |
| EP-1673349-A4 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S BIO PTE LTD (SG) | 2008-01-23 | — | — | EP | claimed |
| JP-2007505942-A | — | — | 2007-03-15 | — | — | JP | claimed |
| EP-1673349-A1 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*Bio Pte Ltd (SG) | 2006-06-28 | — | — | EP | claimed |
| WO-2005028447-A1 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*BIO PTE LTD (SG) | 2005-03-31 | — | — | WO | claimed |
| EP-0139614-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING FLAVANONE OR THIOFLAVANONE DERIVATIVES, THE USE THEREOF, NOVEL FLAVANONES AND THIOFLAVANONES, AND PROCESSES FOR THEIR MANUFACTURE | Zyma SA (CH) | 1990-08-22 | — | — | EP | claimed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | claimed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | claimed |
| CN-113307772-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-114349703-B | Trifluoromethyl-4-cyano pyrazole compound, and preparation method and application thereof | 天津大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-114349703-A | Trifluoromethyl-4-cyanopyrazole compound, and preparation method and application thereof | 天津大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-108430994-B | Compounds, compositions and methods for modulating CFTR | 蛋白质平衡治疗股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-113307772-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2021-08-27 | — | — | CN | disclosed |
| EP-0381434-A1 | Process for producing optically active alcohol | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-08-08 | — | — | EP | disclosed |
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0311385-A2 | Optically active hydroxybenzylamine derivative, optically active amine-boron compound containing said derivative, and process for producing optically active compound by using said compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-04-12 | — | — | EP | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |
| US-4176184-A | CARDIOTONICS, HYPOTENSIVES, ANTITHROMBOTICS AND ANTIARRHYTHMICS | BOEHRINGER INGELHEIM GMBH (DE) | 1979-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057955-A1 | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) | KDM1B, KDM1A, KDM3B | HTR1A 2454/4885ADRA1D 4068/4885ADRA1A 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.