SCHEMBL376751

SCHEMBL376751

CCn1c(=O)c(CCC(=O)O)c(-c2cccc(Cl)c2)c2ccc(C)nc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 1/20 0.46
KDM4E B2RXH2 5/20 0.44
ALDH1A1 P00352 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
LMNA P02545 2/20 0.41
HTT P42858 2/20 0.41
GAA P10253 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.41
RXRA P19793 3/20 0.39
RXRB P28702 3/20 0.39
RXRG P48443 3/20 0.39
NR4A2 P43354 1/20 0.39
GLA P06280 1/20 0.39
DPP4 P27487 1/20 0.39
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372375 1.00 ADORA1 (0.46) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6223187 0.95 ADORA1 (0.45) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6220910 0.92 KDM4E (0.44) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6224664 0.91 KDM4E (0.43) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6223285 0.91 KDM4E (0.45) KDM4EALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6221221 0.90 ADORA1 (0.47) ADORA1KDM4EALDH1A1HSD17B10LMNA
SCHEMBL6792756 0.90 ADORA1 (0.47) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6220833 0.90 KDM4E (0.44) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6222464 0.90 KDM4E (0.42) ADORA1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL6220853 0.89 KDM4E (0.46) ADORA1KDM4EALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1685849-B1 PDE 4 INHIBITORS FOR THE TREATMENT OF INTERSTITIAL CYSTITIS ASTELLAS PHARMA INC (JP) 2012-01-25 EP claimed
US-20070167450-A1 Agent for treating chronic pelvic pain syndrome ASTELLAS PHARMA INC. 2007-07-19 US claimed
EP-1685849-A1 REMEDY FOR CHRONIC PELVIC PAIN SYNDROME Astellas Pharma Inc. (JP) 2006-08-02 EP claimed
EP-1225173-B1 NAPHTHYRIDINE DERIVATIVES ASTELLAS PHARMA INC (JP) 2005-09-28 EP claimed
US-6740662-B1 HAVING 2-OXO-1,2-DIHYDRO- FUNCTIONALITY; PHOSPHODIESTERASE INHIBITORS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-25 US claimed
CN-1148369-C 1,8-naphthyridine derivatives ֮����ҩ��ʽ���� 2004-05-05 CN claimed
CN-1382141-A 1,8-naphthyridine derivatives YAMANOUCHI PHARMA CO LTD (JP) 2002-11-27 CN claimed
EP-1225173-A1 NAPHTHYRIDINE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2002-07-24 EP claimed
US-20230009902-A1 TREATMENT OF A DISEASE OR CONDITION IN A TISSUE ORGINATING FROM THE ENDODERM GLAS USA LLC 2023-01-12 US disclosed
US-20210031012-A1 TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A PDE4 INHIBITOR GLAS USA LLC 2021-02-04 US disclosed
US-20200323772-A1 TREATMENT OF INFLAMMATORY DISEASE USING INGESTIBLE DEVICE TO RELEASE IMMUNE MODULATOR BT BIDCO LLC 2020-10-15 US disclosed
WO-2019246317-A9 TREATMENT OF A DISEASE OR CONDITION IN A TISSUE ORIGINATING FROM THE ENDODERM PROGENITY, INC. (US) 2020-07-16 WO disclosed
WO-2019147824-A1 TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A PDE4 INHIBITOR PROGENITY, INC. (US) 2019-08-01 WO disclosed
WO-2019036382-A1 TREATMENT OF INFLAMMATORY DISEASE USING INGESTIBLE DEVICE TO RELEASE IMMUNE MODULATOR PROGENITY INC. (US) 2019-02-21 WO disclosed
EP-1486204-A1 POWDERY MEDICINAL COMPOSITIONS FOR INHALATION AND PROCESS FOR PRODUCING THE SAME YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2004-12-15 EP disclosed
US-20040184995-A1 Novel dry powder inhalation for lung-delivery and manufacturing method thereof YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2004-09-23 US disclosed
US-6740662-B1 HAVING 2-OXO-1,2-DIHYDRO- FUNCTIONALITY; PHOSPHODIESTERASE INHIBITORS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-25 US disclosed
CN-1148369-C 1,8-naphthyridine derivatives ֮����ҩ��ʽ���� 2004-05-05 CN disclosed
CN-1382141-A 1,8-naphthyridine derivatives YAMANOUCHI PHARMA CO LTD (JP) 2002-11-27 CN disclosed
EP-1225173-A1 NAPHTHYRIDINE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2002-07-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210031012-A1 TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A PDE4 INHIBITOR PDE4A, PDE12, PDE4B ADORA1 2391/4885KDM4E 1259/4885ALDH1A1 2119/4885
US-20230009902-A1 TREATMENT OF A DISEASE OR CONDITION IN A TISSUE ORGINATING FROM THE ENDODERM ALPG, ALPP, FABP2 ADORA1 3616/4885KDM4E 2618/4885ALDH1A1 3155/4885
US-20200323772-A1 TREATMENT OF INFLAMMATORY DISEASE USING INGESTIBLE DEVICE TO RELEASE IMMUNE MODULATOR LRBA, CD47, FABP2 ADORA1 563/4885KDM4E 2278/4885ALDH1A1 2132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.